Arginase (L-arginine ureohydrolase) is present in mammals and plants. In humans, arginase is expressed predominantly in the liver, and to lesser degrees in breast, kidney, testes, salivary glands, epidermis, and erythrocytes. Arginase catalyzes the conversion of arginine to ornithine and urea, completing the last step in the urea cycle. Arginase activity is a key diagnostic indicator. Increased levels of arginase activity in blood have been associated with liver damage. Hyperargininemia due to arginase deficiency is an inherited autosomal recessive disease.
Features and Benefits
Detection limit: 0.3 U/L
Compatible with high-throughput handling systems.
Suitability
The kit is suitable for the determination of arginase activity in enzyme preparations, serum, plasma, tissue culture etc., as well as for studying the effects of drugs on arginase activity.
Principle
The Arginase Assay Kit provides a sensitive and convenient method for arginase activity determination. The method utilizes a chromogen that forms a colored complex specifically with urea produced in the arginase reaction. The intensity of the color is directly proportional to the arginase activity in the sample.
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