M8523
Anti-β2-Microglobulin antibody produced in rabbit
whole antiserum
Synonym(s):
Anti-B2MG
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About This Item
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
human
packaging
antibody small pack of 25 μL
technique(s)
indirect ELISA: 1:5,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... B2M(567)
General description
β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily.
β2-microglobulin (B2M) is a non-glycosylated polypeptide. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.
Immunogen
β2-microglobulin
Application
Anti-β2-Microglobulin antibody produced in rabbit has been used in immunoblottingand immunofluorescence.
Biochem/physiol Actions
β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis.
β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).
Quality
The antiserum has been treated to remove lipoprotens.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Certificates of Analysis (COA)
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Damien G Noone et al.
Kidney international, 90(1), 123-134 (2016-05-30)
Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise
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Kiskova T, et al.
Placenta, 78, 36-43 (2019)
Aruna P Ambagala et al.
Archives of virology, 158(5), 955-965 (2012-12-13)
Cynomolgus macaques are widely used as an animal model in biomedical research. We have established an immortalized cynomolgus macaque fibroblast cell line (MSF-T) by transducing primary dermal fibroblasts isolated from a 13-year-old male cynomolgus macaque with a retrovirus vector expressing
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Su SC, et al.
The Journal of Biological Chemistry, 285(52), 40624-40634 (2010)
The prognostic significance of Beta2 microglobulin in patients with hemophagocytic lymphohistiocytosis
Jiang T, et al.
Disease Markers, 2016 (2016)
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