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J4250

Sigma-Aldrich

JKC 302

≥97% (HPLC)

Synonym(s):

cyclo(D-Ser-Pro-D-Val-Leu-D-Trp)

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About This Item

Empirical Formula (Hill Notation):
C30H42N6O6
CAS Number:
153982-38-8
Molecular Weight:
582.69
MDL number:
MFCD00270699
UNSPSC Code:
12352200
PubChem Substance ID:
329815734

Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CO)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC1=O)C(C)C

InChI

1S/C30H42N6O6/c1-16(2)12-21-26(38)32-22(13-18-14-31-20-9-6-5-8-19(18)20)27(39)34-23(15-37)30(42)36-11-7-10-24(36)28(40)35-25(17(3)4)29(41)33-21/h5-6,8-9,14,16-17,21-25,31,37H,7,10-13,15H2,1-4H3,(H,32,38)(H,33,41)(H,34,39)(H,35,40)/t21-,22+,23+,24-,25+/m0/s1

InChI key

FLVWONZBLRGQPK-VCDBXAJLSA-N

Biochem/physiol Actions

JKC-302 may be used as an endothelin receptor (eta) antagonist similar to JKC-301 and other cyclic D-amino acid containing pentapeptides.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J E Tanus-Santos et al.
Anesthesia and analgesia, 90(1), 102-106 (2000-01-07)
Endothelin (ET) is involved in the humoral component of the vasoconstriction during pulmonary embolism. We examined the effects of selective ET receptor antagonists on the hemodynamic and respiratory changes and on serum thromboxane B2 (TXB2) levels, during a continuous venous
L C Ngoka et al.
Journal of mass spectrometry : JMS, 35(2), 265-276 (2000-02-19)
We previously showed by using mass spectrometry that endothelin A selective receptor antagonists BQ123 and JKC301 form novel coordination compounds with sodium ions. This property may underlie the ability of an ET(A) antagonist to induce net tubular sodium reabsorption in
Daphne Merkus et al.
American journal of physiology. Heart and circulatory physiology, 288(5), H2088-H2092 (2005-01-08)
Alpha-adrenergic vasoconstriction in the coronary circulation is mediated through alpha-adrenoceptors on cardiac myocytes and subsequent release of endothelin, a very potent, long-lasting vasoconstrictor. Recent studies found that adult cardiac myocytes do not express the preproendothelin gene. Thus we hypothesized that

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