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I1909

Immethridine hydrobromide

Name: Immethridine hydrobromide
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-(1H-Imidazol-4-ylmethyl)pyridine hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₉H₉N₃ · xHBr

CAS Number:

87976-03-2

Molecular Weight:

159.19 (free base basis)

MDL number:

MFCD07370139

UNSPSC Code:

12352200

PubChem Substance ID:

24724509

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~10 mg/mL
H₂O: insoluble

SMILES string

Br[H].C(c1ccncc1)c2c[nH]cn2

InChI

1S/C9H9N3.BrH/c1-3-10-4-2-8(1)5-9-6-11-7-12-9;/h1-4,6-7H,5H2,(H,11,12);1H

InChI key

XAOXYOKDVRPLBH-UHFFFAOYSA-N

Biochem/physiol Actions

Potent, highly selective H₃histamine receptor agonist

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.

Ruengwit Kitbunnadaj et al.

Journal of medicinal chemistry, 47(10), 2414-2417 (2004-04-30)

In this study, the piperidine ring of immepip and its analogues was replaced by a rigid heterocyclic pyridine ring. Many compounds in the series exhibit high affinity and agonist activity at the human histamine H(3) receptor. Particularly, the 4-pyridinyl analogue

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