I0274
myo-Inositol Monophosphatase from bovine brain
lyophilized powder, 5-20 units/mg protein
Synonym(s):
myo-Inositol monophosphate phosphohydrolase
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
Pricing and availability is not currently available.
Recommended Products
form
lyophilized powder
specific activity
5-20 units/mg protein
composition
Protein, ~0.5% Bradford
storage temp.
−20°C
Looking for similar products? Visit Product Comparison Guide
Application
The enzyme plays a critical role in the recycling of inositol to phosphoinositides in the mammalian brain and participates in the phosphatidylinositol signaling pathway. It is inhibited non-competitively by Li+, which may be significant in the treatment of manic depression. The enzyme may help in identifying less toxic substitutes for lithium in manic depressive therapy.
Unit Definition
One unit will form 1.0 μmole of phosphate from inositol 1-phosphate per min at pH 7.4 at 37°C.
Physical form
Lyophilized powder containing HEPES buffer salts, pH 7.5, and stabilizer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
S J Pollack et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5766-5770 (1994-06-21)
myo-Inositol monophosphatase (myo-inositol-1-phosphate phosphohydrolase, EC 3.1.3.25) is an attractive target for mechanistic investigation due to its critical role in the phosphatidylinositol signaling pathway and the possible relevance of its inhibition by Li+ to manic depression therapy. The x-ray crystallographic structure
Christopher A Broberg et al.
Science (New York, N.Y.), 329(5999), 1660-1662 (2010-08-21)
The marine bacterium Vibrio parahaemolyticus causes gastroenteritis in humans and encodes the type III effector protein VPA0450, which contributes to host cell death caused by autophagy, cell rounding, and cell lysis. We found that VPA0450 is an inositol polyphosphate 5-phosphatase
Svetlana Kalujnaia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3981-3991 (2010-06-16)
This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its role in salinity adaptation in the eel. The coding sequence of eel IMPA1 was determined and confirmed to be orthologous to the mammalian gene/enzyme by
Sudipta Bhattacharyya et al.
Biochimie, 94(3), 879-890 (2011-12-27)
Inositol monophosphatase (IMPase) family of proteins are Mg(2+) activated Li(+) inhibited class of ubiquitous enzymes with promiscuous substrate specificity. Herein, the molecular basis of IMPase substrate specificity is delineated by comparative crystal structural analysis of a Staphylococcal dual specific IMPase/NADP(H)
A Gupta et al.
The pharmacogenomics journal, 12(4), 328-341 (2011-03-09)
The overall neurobiological mechanisms by which lithium and valproate stabilize mood in bipolar disorder patients have yet to be fully defined. The therapeutic efficacy and dissimilar chemical structures of these medications suggest that they perturb both shared and disparate cellular
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
