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H158

Sigma-Aldrich

[des-Arg10]-HOE 140

synthetic, >98%, powder

Synonym(s):

D-Arg-L-Arg-L-prolyl-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C53H77N15O12S
Molecular Weight:
1148.34
UNSPSC Code:
12352200
PubChem Substance ID:
329815170

biological source

synthetic

Assay

>98%

form

powder

color

white

storage temp.

−20°C

SMILES string

N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3cccs3)C(=O)N[C@@H](CO)C(=O)N4Cc5ccccc5C[C@@H]4C(=O)N6[C@H]7CCCC[C@H]7C[C@H]6C(O)=O

InChI

1S/C53H77N15O12S/c54-34(13-5-17-59-52(55)56)44(72)63-35(14-6-18-60-53(57)58)47(75)65-19-7-16-39(65)49(77)67-27-32(70)23-40(67)46(74)61-25-43(71)62-36(24-33-12-8-20-81-33)45(73)64-37(28-69)48(76)66-26-31-11-2-1-9-29(31)21-41(66)50(78)68-38-15-4-3-10-30(38)22-42(68)51(79)80/h1-2,8-9,11-12,20,30,32,34-42,69-70H,3-7,10,13-19,21-28,54H2,(H,61,74)(H,62,71)(H,63,72)(H,64,73)(H,79,80)(H4,55,56,59)(H4,57,58,60)/t30-,32+,34+,35-,36-,37-,38-,39-,40-,41+,42-/m0/s1

InChI key

TZWJLAAYNDPYBS-ZYEJRSMVSA-N

Amino Acid Sequence

D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic

Biochem/physiol Actions

Potent B1 bradykinin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Des Arg10 [Hoe 140] is a potent B1 bradykinin antagonist.
Wirth, et al.
Agents and Actions (Suppl.), 38, 406-406 (1992)
N E Rhaleb et al.
Life sciences, 51(11), PL125-PL129 (1992-01-01)
Two new B1 receptor antagonists, [Hyp3,Thi5,DTic7,Oic8]desArg9-BK and DArg[Hyp3,Thi5,DTic7,Oic8]desArg9-BK were tested in vitro on the rabbit jugular vein and the guinea pig ileum (preparations containing B2 receptors) and on the rabbit aorta (preparation containing B1 receptors) for pharmacological characterization. The results

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