Immunogen Sequence: GI # 14591926, sequence 219-530
Recombinant sec23 (S. cerevisiae) homolog B
Application
Anti-SEC23B antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Protein transport protein Sec23B is a protein encoded by the SEC23B gene in humans. Mutation in this gene is associated with CDAII disease and it also results in a significant decrease of SEC23B transcript in erythroid precursors. Decreased Sec23B protein levels in erythroid precursors is correlated with down-regulation of the SEC23B mRNA transcript.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Orphanet journal of rare diseases, 6, 89-89 (2012-01-03)
Congenital dyserythropoietic anemia type II (CDAII), the most common form of CDA, is an autosomal recessive condition. CDAII diagnosis is based on invasive, expensive, and time consuming tests that are available only in specialized laboratories. The recent identification of SEC23B
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