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G6132

Sigma-Aldrich

Glycodeoxycholic acid monohydrate

≥97% (TLC)

Synonym(s):

3α,12α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Linear Formula:
C26H43NO5
CAS Number:
360-65-6
Molecular Weight:
467.64
Beilstein:
2954947
MDL number:
MFCD00150922
UNSPSC Code:
12161900
PubChem Substance ID:
24895246

description

anionic

Assay

≥97% (TLC)

SMILES string

[H]O[H].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.H2O/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);1H2/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;/m1./s1

InChI key

DLOTUJUSJVIXDW-YEUHZSMFSA-N

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Biochem/physiol Actions

Induces apoptosis in hepatocytes; may induce DNA cleavage.

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Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yong Zhou et al.
American journal of physiology. Gastrointestinal and liver physiology, 298(5), G722-G731 (2010-03-06)
The injurious effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the small intestine was not appreciated until the widespread use of capsule endoscopy. Animal studies found that NSAID-induced small intestinal injury depends on the ability of these drugs to be secreted
Sandeep Khurana et al.
PloS one, 7(2), e32006-e32006 (2012-02-24)
Bile acids (BAs) regulate cardiovascular function via diverse mechanisms. Although in both health and disease serum glycine-conjugated BAs are more abundant than taurine-conjugated BAs, their effects on myogenic tone (MT), a key determinant of systemic vascular resistance (SVR), have not
Kai A Bachmann et al.
Critical care (London, England), 17(6), R281-R281 (2013-12-10)
Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, microcirculation, tissue oxygenation and histopathologic damage in an experimental
Lutz Schneider et al.
Pancreas, 38(6), 676-680 (2009-07-25)
Calcitonin gene-related peptide (CGRP) is released from perivascular pancreatic nerves. It effects vasomotion and cytokine liberation in inflammatory processes, including acute pancreatitis (AP). Calcitonin gene-related peptide liberation is stimulated by capsaicin, a substance of red hot chili peppers. Aim of
Jesper Østergaard et al.
Journal of separation science, 32(10), 1712-1721 (2009-05-28)
The practical and theoretical problems associated with interpretation of binding isotherms obtained by the investigation of weak analyte-ligand interactions using mobility shift affinity CE were investigated with special emphasis on various correction methods to compensate for media effects due to
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