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E0881

Sigma-Aldrich

Elastatinal

powder

Synonym(s):

(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide

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5 MG
$263.00
10 MG
$434.00
25 MG
$860.00

$263.00

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5 MG
$263.00
10 MG
$434.00
25 MG
$860.00

About This Item

Empirical Formula (Hill Notation):
C21H36N8O7
CAS Number:
51798-45-9
Molecular Weight:
512.56
Beilstein:
873543
EC Number:
257-426-7
MDL number:
MFCD00151180
UNSPSC Code:
12352202
PubChem Substance ID:
24894375
NACRES:
NA.77

$263.00

Please contact Customer Service for Availability
Request a Bulk Order

Product Name

Elastatinal, microbial

biological source

microbial

form

powder

solubility

water: 20 mg/mL, clear, faintly yellow to yellow

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1

InChI

1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI key

IJWCGVPEDDQUDE-YGJAXBLXSA-N

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Biochem/physiol Actions

Potent, irreversible elastase inhibitor.
Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW8515
MKCV6276
MKCS8836
MKCR6040
MKCQ4656

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D J Rigby et al.
Biochimica et biophysica acta, 661(2), 315-322 (1981-10-13)
The pyrimidine-3 gene of Neurospora crassa codes for a bifunctional enzyme catalysing the first two steps of the pyrimidine biosynthetic pathway. Difficulties have been experienced in purification due to the lability of the enzyme. The enzyme loses carbamoyl-phosphate synthetase (carbon-dioxide:
L Chen et al.
Archives of microbiology, 153(1), 90-94 (1989-01-01)
The effect of the removal of signal peptides after cleavage of precursor molecules by the signal peptidase I was examined in an in vitro translocation system with Escherichia coli membrane vesicles. The translocation of periplasmic alkaline phosphatase precursors was significantly
The effect of low-molecular-weight inhibitors on the growth in vitro of a human pancreatic adenocarcinoma cell line.
A G Grant et al.
Biochemical Society transactions, 9(1), 134-134 (1981-02-01)
K Marossy et al.
Biochimica et biophysica acta, 615(1), 237-245 (1980-09-09)
The extracts of granules isolated from bovine granulocytes show elastase- and chymotrypsin-like activities, as detected with specific synthetic substrates. Extraction of these enzymes depends upon salt concentration. In the course of the present studies a 21-fold purification of the elastase-like
De-Peng Jiang et al.
Journal of Korean medical science, 26(6), 778-784 (2011-06-10)
Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial epithelial 16 (HBE16) cells were pretreated with scutellarin for 60
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