BM0023

BMS-770767

≥98% (HPLC)

• Synonym(s): 4-[8-(2-Chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-bicyclo[2.2.1]heptan-1-ol
• Empirical Formula (Hill Notation): C₁₉H₁₈ClN₃O₂
• CAS Number: 1875067-34-7
• Molecular Weight: 355.82
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774366
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: ClC1=C(OC2=CC=CN3C2=NN=C3[C@]4(C5)CC[C@]5(O)CC4)C=CC=C1
• InChI: 1S/C19H18ClN3O2/c20-13-4-1-2-5-14(13)25-15-6-3-11-23-16(15)21-22-17(23)18-7-9-19(24,12-18)10-8-18/h1-6,11,24H,7-10,12H2/t18-,19+
• InChI key: HNXGIFYHJKEXNA-KDURUIRLSA-N

Description

Biochem/physiol Actions

BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I (11β-HSD1), which is a regulator of glucocorticoid activity and thought to play a possible role in metabolic syndrome. 11β-HSD1 can convert cortisol to the inactive metabolite cortisone, or catalyze the reverse reaction, converting inactive cortisone into active cortisol in cells. BMS-770767 was in clinical trials for hypercholesterolemia and Type 2 diabetes.

Features and Benefits

BMS-770767 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable