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A9229

Sigma-Aldrich

Ac-Lys-(Me)Leu-Val-(Me)Phe-Phe-NH2 trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

Aβ16-20m

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About This Item

Empirical Formula (Hill Notation):
C39H59N7O6 · xC2HF3O2
CAS Number:
461640-33-5
Molecular Weight:
721.93 (free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
329771042
NACRES:
NA.77

Assay

≥95% (HPLC)

form

powder

color

white

solubility

H2O: >1 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](N(C)C(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc2ccccc2)C(N)=O

InChI

1S/C39H59N7O6.C2HF3O2/c1-25(2)22-32(45(6)38(51)30(42-27(5)47)20-14-15-21-40)37(50)44-34(26(3)4)39(52)46(7)33(24-29-18-12-9-13-19-29)36(49)43-31(35(41)48)23-28-16-10-8-11-17-28;3-2(4,5)1(6)7/h8-13,16-19,25-26,30-34H,14-15,20-24,40H2,1-7H3,(H2,41,48)(H,42,47)(H,43,49)(H,44,50);(H,6,7)/t30-,31?,32-,33-,34-;/m0./s1

InChI key

FTNLRFFNHYISOF-KOLCXYLVSA-N

Amino Acid Sequence

Ac-Lys-Me-Leu-Val-Me-Phe-Phe-NH2

Biochem/physiol Actions

Amyloid β40 fibrillogenesis inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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D J Gordon et al.
The journal of peptide research : official journal of the American Peptide Society, 60(1), 37-55 (2002-06-26)
Alzheimer's disease, Huntington's disease and prion diseases are part of a growing list of diseases associated with formation of beta-sheet containing fibrils. In a previous publication, we demonstrated that the self-association of the Alzheimer's beta-amyloid (Abeta) peptide is inhibited by
David J Gordon et al.
Biochemistry, 42(2), 475-485 (2003-01-15)
Protein-protein interactions are frequently mediated by stable, intermolecular beta-sheets. A number of cytokines and the HIV Protease, for example, dimerize through beta-sheet motifs. Evidence also suggests that the macromolecular assemblies of peptides and proteins in amyloid fibrils are stabilized by

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