β-arrestin-1 is a scaffold protein that is highly expressed in the central nervous system. This adaptor protein regulates mitogenic signaling, and also mediates the desentization and internalization of G protein coupled receptors (GPCRs). Rabbit Anti-phospho-β-Arrestin (pSer412) antibody detects mouse and rat β-arrestin-1. The antibody is also expected to react with human and cow antigens due to the high degree of homology (77%).
Immunogen
synthetic phosphopeptide derived from the region of rat β-arrestin-1 that contains serine 412.
Application
Rabbit Anti-phospho-beta-Arrestin (pSer412) antibody can be used for western blot assays.
Physical form
Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium azide.
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