The molecular weight is not determined for this product. An internal note suggests the antifoam's molecular weight is approximately 3,000 daltons, but this is not verified.
A6426
Antifoam 204
mixture of organic polyether dispersions
Synonym(s):
organic antifoam
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100 G
$77.00
500 G
$147.00
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$252.00
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100 G
$77.00
500 G
$147.00
1 KG
$252.00
About This Item
Recommended Products
biological source
synthetic
Quality Level
form
liquid
technique(s)
microbiological culture: suitable
viscosity
400 cP(lit.)
density
1.01 g/cm3 at 25 °C (lit.)
storage temp.
room temp
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General description
Antifoam function as an effective foam suppressor.[1] Antifoam 204 contains 100% active components and is a mixture of organic non-silicone polypropylene-based polyether dispersions. It does not contain mineral oil. Antifoam 204 can itself be considered a surfactant, but it contains no other surfactants. This product is synthetic and not derived from animal or plant sources. Antifoam 204 can be sterilized repeatedly. The flow properties of Antifoam 204 are such that it can be pumped to a fermenter on an as-needed basis. For use in microbiological media, Sigma recommends a starting concentration of between 0.005% and 0.01%.
Application
Features and Benefits
- Highly versatile surfactant for your cell biology and biochemical research
- Suitable for microbiological culture
Other Notes
Contains 100% active components and is a mixture of non-silicone organic defoamers in a polyol dispersion. Can be sterilized repeatedly.
For additional information on our range of Biochemicals, please complete this form.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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What is the molecular weight of this product? Mean and dispersion? We are trying to assess passage through membranes.
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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May i ask if you have the toxicological safety data (such as LD50) of Antifoam 204 (Cat # A6426)?
1 answer-
The toxicological data can be found in Section 11 of the Safety Data Sheet. This document may be accessed by entering the product number in the SDS section at the link below: https://www.sigmaaldrich.com/documents-search?tab=sds
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I am using Antifoam 204 in vaccine fermentation process as an antifoaming agent. Regulatory expectation is to varify residual content of 204 in final product. Do you have any suggestion on which analytical method should one explore for such a characteriza
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This product is intended for research use only. It is not suitable for human or veterinary use. Unfortunately, a method for residual detection is not available. However, a brief search of the literature reveals that several methods may be deployed, including LC/MS/MS and LS/CAD. Please see the links below to review publications regarding testing for residual amounts of antifoam.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/j.2050-0416.1977.tb06809.x
https://www.eurofinsus.com/media/447588/9207_residual_impurities_bioprocessing.pdf
https://www.bioprocessintl.com/process-monitoring-and-controls/analytical-strategies-for-monitoring-residual-impurities-encountered-in-bioprocessingResidual level tests for antifoam may require a dedicated piece of equipment due to the antifoam properties.
Various general recommendations may be of interest:
a. Use an antifoam sensor/ probe or pump to measure the amount of antifoam in solution
b. NMR
c. ViscosityHelpful?
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Quelle est la molécule du antifoam 204? Est ce un polyethylene glycol classique?
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Antifoam 204 contains 100% active components and is a mixture of organic non-silicone polypropylene-based polyether dispersions. It does not contain mineral oil. The exact composition is considered proprietary by the supplier.
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May I ask if you have the LD50 information of Antifoam 204 (Cat#A6426)?
1 answer-
Unfortunately, there is no LD50 information available for this product. A brief search of the literature revealed a publication that reports an LD50 of > 5000 mg/kg in rats. Please see the link below to review this article:
https://www.sciencedirect.com/science/article/abs/pii/B9781774670088500092Helpful?
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