Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

A256

Sigma-Aldrich

9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride

>97%, solid

Synonym(s):

heptylene-bis(THA) dihydrochloride, heptylene-bis(tacrine) dihydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C33H40N4 · 2HCl
CAS Number:
224445-12-9
Molecular Weight:
565.62
MDL number:
MFCD08062163
UNSPSC Code:
12352202
PubChem Substance ID:
24890669

Assay

>97%

form

solid

color

white

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Cl.C(CCCNc1c2CCCCc2nc3ccccc13)CCCNc4c5CCCCc5nc6ccccc46

InChI

1S/C33H40N4.2ClH/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33;;/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37);2*1H

InChI key

RHKXINFBJWDTSK-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Caution

Extremely hygroscopic; store desiccated

Legal Information

Sold under exclusive license from Mayo Foundation for Medical Education and Research.

replaced by

Product No.
Description
Pricing

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase.
Pang, et al.
Journal of the Chemical Society. Perkin Transactions 1, 171-171 (1997)
Y P Pang et al.
The Journal of biological chemistry, 271(39), 23646-23649 (1996-09-27)
We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand docking with target proteins: 1) identify low affinity sites normally missed by x-ray crystallography; and 2)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service