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Key Documents

A0726

Sigma-Aldrich

Activin Receptor-Like Kinase 7/Fc Chimera from rat

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

ALK-7

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About This Item

MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

rat

recombinant

expressed in NSO cells

Assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

47-55 kDa by SDS-PAGE (reducing)
calculated mol wt ~35.7 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

Biochem/physiol Actions

ALK-7 is a type I receptor of the serine/threonine kinases and is expressed in the adult central nervous system. Type I and II receptors bind ligands in the TGF-β superfamily.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

Can be used as a calibrator for ALK-7 antibodies.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Rydén et al.
The Journal of biological chemistry, 271(48), 30603-30609 (1996-11-29)
Receptor serine-threonine kinases (RSTK) mediate inhibitory as well as stimulatory signals for growth and differentiation by binding to members of the transforming growth factor-beta (TGF-beta) superfamily. Over 12 different RSTKs have been isolated so far, displaying wide expression in peripheral
P ten Dijke et al.
Oncogene, 8(10), 2879-2887 (1993-10-01)
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity

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