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H3149

Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture

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About This Item

CAS Number:
9041-08-1
MDL number:
MFCD00081689
UNSPSC Code:
12352201
NACRES:
NA.21

biological source

Porcine intestinal mucosa

Quality Level

200

type

Grade I-A

product line

BioReagent

form

powder

specific activity

≥180 USP units/mg

technique(s)

analytical sample preparation: suitable
cell culture | mammalian: suitable

color

beige

solubility

H2O: 50 mg/mL

application(s)

cell analysis
diagnostic assay manufacturing
life science and biopharma
sample preparation

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General description

Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.
Heparin sodium, a sulfated polysaccharide from the glycosaminoglycan family, plays a vital role in cell culture, cancer biology, and drug discovery research. Its impact on protein and cell interactions makes it valuable for studying molecular and cellular processes, tumor modeling, exploring binding interactions, and as a cell culture supplement to support cell viability.

Application

  • Heparin sodium salt from porcine intestinal mucosa has been used in sLRP (soluble circulating low density lipoprotein receptor-related protein-1) purification from human plasma.
  • It has been used as a supplement in M199 medium for culturing of human umbilical vein endothelial cells.
  • It has been used as an anticoagulant agent during isolation of blood.

Features and Benefits

  • High-purity compound suitable for a wide variety of research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000402273
0000402275
0000402277
0000402278
0000402276

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Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.
Bachli EB et al.
Journal of Thrombosis and Haemostasis, 1, 1935-1935 (2003)
Structure of the antithrombin-binding site in heparin.
Lindahl U et al.
Proceedings of the National Academy of Sciences of the USA, 76, 3198-3202 (1979)
Mohamed Abdouh et al.
Journal of experimental & clinical cancer research : CR, 36(1), 113-113 (2017-09-01)
Horizontal transfer of malignant traits from the primary tumor to distant organs, through blood circulating factors, has recently become a thoroughly studied metastatic pathway to explain cancer dissemination. Recently, we reported that oncosuppressor gene-mutated human cells undergo malignant transformation when
Keisuke Yoshida et al.
Nature communications, 9(1), 3885-3885 (2018-09-27)
The majority of histones are replaced by protamines during spermatogenesis, but small amounts are retained in mammalian spermatozoa. Since nucleosomes in spermatozoa influence epigenetic inheritance, it is important to know how histones are distributed in the sperm genome. Conflicting data
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-? is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.
Sagare AP et al.
Journal of Alzheimer'S Disease, 24, 25-25 (2011)
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