96708

Phosphonoacetic acid

TraceCERT^®, ³¹P-qNMR Standard, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• Linear Formula: (HO)₂P(O)CH₂CO₂H
• CAS Number: 4408-78-0
• Molecular Weight: 140.03
• EC Number: 224-558-1
• MDL number: MFCD00004311
• UNSPSC Code: 41116107
• PubChem Substance ID: 329770527
• NACRES: NA.24

Properties

• Quality Level: 300
• product line: TraceCERT^®
• grade: TraceCERT^®
• form: solid
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• technique(s): qNMR: suitable
• mp: 143-146 °C (lit.)
• application(s): cleaning products; cosmetics; flavors and fragrances; food and beverages; personal care; pharmaceutical
• SMILES string: OC(=O)CP(O)(O)=O
• InChI: 1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
• InChI key: XUYJLQHKOGNDPB-UHFFFAOYSA-N

Description

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.


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Application

• Enhancing Guide RNA Stability and Editing Yields: Phosphonoacetate modifications have been shown to significantly enhance the stability and editing efficiency of guide RNAs for Cas9-based genome editors. This development has profound implications in genetic engineering and therapeutic applications, where precision and stability are crucial (Ryan et al., 2023).


• Glomerular and Tubulointerstitial Nephropathy Study: Phosphonoacetic acid has been indirectly related to studies on kidney diseases such as glomerular and tubulointerstitial nephropathy, showcasing its potential relevance in medical research to understand and treat complex renal conditions (Pleško et al., 2021).


• Environmental Impact of Phosphonoacetate: Research on PMIDA-modified magnetic nanoparticles, including those related to phosphonoacetate, explores their application in liver MRI, indicating its utility in enhancing diagnostic imaging techniques and its potential environmental implications (Demin et al., 2018).


• CRISPR-Cas Specificity Improvement: Modifications including phosphonoacetate derivatives have been employed to improve the specificity and efficiency of CRISPR-Cas systems in gene editing, underscoring the chemical′s role in cutting-edge biotechnological research (Ryan et al., 2018).


• Cardiovascular Pharmacology: Studies involving phosphonoacetic acid have been connected to cardiovascular pharmacology, particularly in exploring the mechanisms that inhibit calcification in vascular tissues, which is vital for developing treatments for vascular calcification diseases (Duan et al., 2017).

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Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable