The British journal of ophthalmology, 103(8), 1112-1118 (2018-10-14)
To report refractive error prevalence and visual impairment in Republic of Ireland (henceforth 'Ireland') schoolchildren. The Ireland Eye Study examined 1626 participants (881 boys, 745 girls) in two age groups, 6-7 years (728) and 12-13 years (898), in Ireland between
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3193-3205 (2015-04-17)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that is most commonly caused by a de novo point mutation in exon 11 of the LMNA gene, c.1824C>T, which results in an increased production of a truncated form of
BNip3 is a hypoxia-inducible protein that targets mitochondria for autophagosomal degradation. We report a novel tumor suppressor role for BNip3 in a clinically relevant mouse model of mammary tumorigenesis. BNip3 delays primary mammary tumor growth and progression by preventing the
Journal of neurophysiology, 114(1), 585-607 (2015-05-15)
Obesity is a worldwide health problem that has reached epidemic proportions. To ameliorate this problem, one approach is the use of appetite suppressants. These compounds are frequently amphetamine congeners such as diethylpropion (DEP), phentermine (PHEN), and bupropion (BUP), whose effects
Immunoglobulins and T cell receptors (TCRs) share common sequences and structures. With the goal of creating novel bispecific antibodies (BsAbs), we generated chimeric molecules, denoted IgG_TCRs, where the Fv regions of several antibodies were fused to the constant domains of
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