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CBL714

Sigma-Aldrich

Anti-CD126 Antibody, clone B-R6

clone B-R6, Chemicon®, from mouse

Synonym(s):

IL-6 Receptor, alpha Chain

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

B-R6, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

NM_000565.2
NM_181359.1

UniProt accession no.

P08887

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... IL6R(3570)

Specificity

This antibody recognizes both the soluble and membrane bound human IL-6 receptor. The antibody will inhibit IL-6 mediated proliferation of XG-1 cells and partially blocks the binding of IL-6 to its receptor.

Immunogen

CHO cells transfected with a cDNA of the human IL-6 receptor.

Application

Flow cytometry: 1:50. Use 10 μL of this dilution to label 10e6 cells in 100 μL.

Immunohistochemistry on frozen sections.

Immunoprecipitation.

ELISA

Optimal working dilutions must be determined by the end user.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
This Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126.

Physical form

Format: Purified
The monoclonal was purified by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.4, containing 0.09% sodium azide.

Storage and Stability

Maintain at 2°-8°C for up to 12 months from date of receipt in undiluted aliquots.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jakob Vejby Larsen et al.
Molecular and cellular biology, 37(11) (2017-03-08)
Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6 have been found to accompany several

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