ABN2246
Anti-PTP zeta/Phosphacan
from rabbit
Synonym(s):
Receptor-type tyrosine-protein phosphatase zeta, EC:3.1.3.48, R-PTP-zeta, 3F8 chondroitin sulfate proteoglycan, 3H1 keratan sulfate proteoglycan, Phosphacan
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
unpurified
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry: suitable (paraffin)
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Gene Information
rat ... Ptprz1(25613)
General description
Receptor-type tyrosine-protein phosphatase zeta (UniProt: Q62656; also known as EC:3.1.3.48, R-PTP-zeta, 3F8 chondroitin sulfate proteoglycan, 3H1 keratan sulfate proteoglycan, Phosphacan) is encoded by the Ptprz1 (also known as Ptprz, Ptpz) gene (GeneID: 25613) in rat. It is a soluble nervous tissue-specific proteoglycan that is thought to regulate axonal outgrowth. It is synthesized by glia and binds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM but not to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell adhesion and neurite outgrowth and negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. It is required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. RPTPzeta has an extracellular domain (aa 25-1637), a transmembrane domain (aa 1638-1663) and a cytoplasmic domain (aa 1664-2316). It is produced with a signal peptide (aa 1-24) that is cleaved to generate the mature form.
Specificity
This rabbit polyclonal antibody specifically detects PTP zeta/Phosphacan in rat brain tissue.
Immunogen
Epitope: unknown
Full length (aa 1-2316) purified Receptor-type tyrosine-protein phosphatase zeta (Phosphacan) isolated from 7-day fetal rat brain.
Application
Anti-phosphacan, Cat. No. ABN2246 is a rabbit polyclonal antibody that has been tested for use in Immunohistochemistry (Paraffin) for the detection of Receptor-type tyrosine-protein phosphatase zeta.
Immunohistochemistry Analysis: A representative lot detected PTP zeta/Phosphacan in E16 rat spinal cord (Milev, P., et. al. (1994). J Cell Biol. 127(6 Pt 1):1703-15), rat brain (Haunso, A., et. al. (1999). Brain Res. 834(1-2):219-22), and 21-day postnatal rat retina, 2-week postnatal rat cerebellum, E13 rat spinal cord (Milev, P., et. al. (1998). J Biol Chem. 273(12):6998-7005).
Research Category
Cell Structure
Cell Structure
Quality
Evaluated by Immunohistochemistry (Paraffin) in rat cerebral cortex and rat hippocampus tissue.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected PTP zeta/Phosphacan in rat cerebral cortex and rat hippocampus tissue.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected PTP zeta/Phosphacan in rat cerebral cortex and rat hippocampus tissue.
Target description
255.34 kDa calculated.
Physical form
Format: Unpurified
Rabbit polyclonal antiserum with 0.02% sodium azide.
Rabbit polyclonal antiserum with 0.02% sodium azide.
Unpurified
Storage and Stability
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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