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AB5702

Sigma-Aldrich

Anti-HES-1 Antibody

Chemicon®, from rabbit

Synonym(s):

Hairy 1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rodent, human, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_005524.2

UniProt accession no.

Q14469

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... HES1(3280)
mouse ... Hes1(15205)

General description

Hes1 is a transcriptional repressor of genes that require a bHLH protein for their transcription. It may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 is expressed in developing neuroectodermal and endodermal endocrine tissues, and Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia.

Specificity

Reactivity with other species has not been confirmed.
Recognizes HES-1 (Hairy family), a Helix-loop-helix class of transcription factor.

Immunogen

Synthetic peptide.

Application

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Neuronal & Glial Markers
This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.
Western Blot:
1:200-1:1,000 dilution using ECL.

Immunohistochemistry:
1:200-1:1,000 dilution of a previous lot worked.

Optimal working dilutions must be determined by the end user.

Target description

29 kDa

Physical form

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Storage and Stability

Stable for 1 year at -80ºC from date of receipt.

Analysis Note

Control
Human neural stem cells, Raji cell lysate.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rute M M Ferreira et al.
Cell reports, 21(4), 966-978 (2017-10-27)
The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on
Sheheryar Kabraji et al.
Breast cancer research : BCR, 19(1), 88-88 (2017-08-03)
Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment responses are likely determined by mechanisms that enable cancer cells to resist being killed.
Cédric S Tremblay et al.
BMC research notes, 11(1), 138-138 (2018-02-22)
The Hairy Enhancer of Split 1 (HES1) is a transcriptional repressor that regulates cellular proliferation and differentiation during development. We previously found an interaction between HES1 and Fanconi anemia (FA) proteins. FA is a hematological and developmental disorder caused by
Notch signaling in descending thoracic aortic aneurysm and dissection.
Zou, S; Ren, P; Nguyen, M; Coselli, JS; Shen, YH; LeMaire, SA
Testing null
Wen-Cheng Chung et al.
Oncoscience, 4(9-10), 131-138 (2017-11-17)
Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether
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