5677

Spermine, Tetrahydrochloride

• Synonym(s): Spermine, Tetrahydrochloride
• Empirical Formula (Hill Notation): C₁₀H₂₆N₄ · 4HCl
• CAS Number: 306-67-2
• Molecular Weight: 348.18
• MDL number: MFCD00012914
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥99% (titration)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• InChI key: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

General description

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Cα and an activator of phospholipase Cδ. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS.

Biochem/physiol Actions

Primary Target
phospholipase C α

Secondary Target
nNOS

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.

Other Notes

Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J.8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int.32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem.124, 141.
Ask, A., et al. 1992. Cancer Lett.66, 29.
Chida, N., et al. 1992. Brain Res.593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys.297, 328.
Shantz, L.M., et al. 1992. Biochem. J.288, 511.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable