567305

SKF-86002

A cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID).

• Synonym(s): SKF-86002, 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole
• Empirical Formula (Hill Notation): C₁₆H₁₂FN₃S
• CAS Number: 72873-74-6
• Molecular Weight: 297.35
• MDL number: MFCD00869367
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
• InChI key: YOELZIQOLWZLQC-UHFFFAOYSA-N

Description

General description

A cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC₅₀ = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.

A cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC₅₀ = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
(LPS)-stimulated IL-1 and TNF-α production

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1 µM inhibiting lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production

Warning

Toxicity: Irritant (B)

Other Notes

Frasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389.
Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63.
Lee, J.C., et al. 1995. Nature 372, 739.
Prichett, W., et al. 1995. J. Inflamm. 45, 97.
Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable