5.05413

5-Iodo-A-85380 dihydrochloride hydrate

• Synonym(s): 5-Iodo-A-85380 dihydrochloride hydrate, 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
• Empirical Formula (Hill Notation): C₉H₁₁IN₂O · 2HCl · xH₂O
• CAS Number: 213550-82-4
• Molecular Weight: 363.02 (anhydrous basis)
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: water: 22 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1
• InChI key: RKVRGRXOYDTUEY-QMMMGPOBSA-N

Description

General description

A very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (K_i= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.

Biochem/physiol Actions

Primary Target
α4β2 nAChR

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Liu, X., et al., 2013. Psychopharm.In press.

Kennett, A., et al., 2012. Nicotine Tob. Res.14, 1339.

Huang. LZ, et al., 2011. Neuropharm.60, 861.
Mogg. AJ, et al., 2004. Neuropharm.60, 861.

Mukhin, A.G., et al., 2000. Mol. Pharmacol.47, 848.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable