Skip to Content
MilliporeSigma
All Photos(2)

Documents

422625

Sigma-Aldrich

KLF5 Inhibitor, CID 5951923

The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5.

Synonym(s):

KLF5 Inhibitor, CID 5951923, 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C16H18N2O7S
CAS Number:
Molecular Weight:
382.39
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.28

Quality Level

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+

InChI key

URVRJYLSUVXWBC-AATRIKPKSA-N

General description

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.
A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.

Other Notes

Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service