362338

Glyco-SNAP-1 - Calbiochem

A water-soluble nitric oxide (NO) donor.

• Synonym(s): Glyco-SNAP-1 - Calbiochem, N-(β-D-Glucopyranosyl)-N²-acetyl-S-nitroso-D,L-penicillaminamide
• Empirical Formula (Hill Notation): C₁₃H₂₃N₃O₈S
• Molecular Weight: 381.40
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥96% (NMR)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: green
• solubility: aqueous buffer: 100 mg/mL; water: 100 mg/mL; methanol: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A water-soluble and stable nitric oxide (NO) donor (t_½ = 28.5-30.2 hr). Glyco-SNAP-1 is more stable than SNAP (Cat. No. 487910) in aqueous solution with or without EDTA and is relatively stable at high pH (pH 8-9). The SNAP moiety acts as an NO group donor and the sugar fragment provides hydrophilicity and specificity. Compared to SNAP, glyco-SNAP-1 decomposes much more slowly in the presence of thiols such as cysteine or glutathione.

A water-soluble nitric oxide (NO) donor. More stable (t_½ = 28.5-30.2 hr) than SNAP (Cat. No. 487910) in aqueous solution with or without EDTA and is relatively stable at high pH (pH 8 - 9). The SNAP moiety acts as an NO group donor and the sugar moiety provides hydrophilicity and specificity. Compared to SNAP, glyco-SNAP-1 decomposes at a much slower rate in the presence of thiols such as cysteine or glutathione.

Biochem/physiol Actions

Cell permeable: no

Primary Target
A water-soluble nitric oxide (NO) donor

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Hou, Y., et al. 1999. Methods Enzymol. 301, 242.
Ramirez, J., et al. 1996. Bioorg. Med. Chem. Lett.6, 2575.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable