Skip to Content
MilliporeSigma
All Photos(1)

Documents

324413

Sigma-Aldrich

Dynamin Inhibitor IV, Hydroxy-Dynasore

The Dynamin Inhibitor IV, Hydroxy-Dynasore controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Synonym(s):

Dynamin Inhibitor IV, Hydroxy-Dynasore, 3-Hydroxynaphthalene-2-carboxylic acid-(2,4,5-trihydroxybenzylidene)-hydrazide

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C18H14N2O5
Molecular Weight:
338.31
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A highly potent (IC50 = 0.38 and 2.6 µM for dynamin I and dynamin II, respectively), cell-permeable and in vivo bioavailable (30 mg/kg in mice, i.p.) hydroxylated analog of Dynamin Inhibitor I, Dynasore (Cat. No. 324410).
A highly potent (IC50 = 0.38 and 2.6 µM for dynamin I and dynamin II, respectively), cell-permeable and in vivo bioavailable (30 mg/kg in mice, i.p.) hydroxylated analog of Dynamin Inhibitor I, Dynasore (Cat. No. 324410).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Harper, C.B., et al. 2011. J. Biol. Chem.286, 35966.
Howes, M.T., et al. 2010. J. Cell Biol.190, 675.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Enikő Pergel et al.
International journal of molecular sciences, 22(19) (2021-10-14)
TMEM175 (transmembrane protein 175) coding sequence variants are associated with increased risk of Parkinson's disease. TMEM175 is the ubiquitous lysosomal K+ channel regulated by growth factor receptor signaling and direct interaction with protein kinase B (PKB/Akt). In the present study

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service