07-476
Anti-p75NTR (Neurotrophin Receptor) Antibody
Upstate®, from rabbit
Synonym(s):
CD271 antigen, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, low affinity nerve growth factor receptor, nerve growth factor receptor, nerve growth factor receptor (TNFR superfamily, member 16), p75 IC
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... NGFR(4804)
General description
The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate.
The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4).
Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron′s target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons.
The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4).
Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron′s target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons.
Specificity
Recognizes p75 neurotrophin receptor, MW ~75 kDa.
Immunogen
Epitope: IC domain
GST fusion protein corresponding to the intracellular domain (residues 274-425) of rat p75 neurotrophin receptor.
Application
Detect p75NTR (Neurotrophin Receptor) using this Anti-p75NTR (Neurotrophin Receptor) Antibody validated for use in IH, IP & WB.
Immunoprecipitation:
This antibody has been reported by an independent laboratory to immunoprecipitate p75 neurotrophin receptor.
Immunohistochemistry:
This antibody has been reported by an independent laboratory to detect p75 neurotrophin receptor in rat brain sections. (Roux, P., 1999)
This antibody has been reported by an independent laboratory to immunoprecipitate p75 neurotrophin receptor.
Immunohistochemistry:
This antibody has been reported by an independent laboratory to detect p75 neurotrophin receptor in rat brain sections. (Roux, P., 1999)
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins
Neurochemistry & Neurotrophins
Quality
Evaluated by western blot in RIPA lysates from PC-12 cells.
Western Blot Analysis:
0.1-0.5 µg/mL of this antibody detected p75 neurotrophin receptor in RIPA lysates from PC-12 cells.
Western Blot Analysis:
0.1-0.5 µg/mL of this antibody detected p75 neurotrophin receptor in RIPA lysates from PC-12 cells.
Target description
~75 kDa
Physical form
Format: Purified
Protein A purified
Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol.
Storage and Stability
Stable for 1 year at -20ºC from date of receipt.
Analysis Note
Control
Brain tissue.
Brain tissue.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.
Ramos, A; Ho, WC; Forte, S; Dickson, K; Boutilier, J; Favell, K; Barker, PA
The Journal of Neuroscience null
E W Neeley et al.
Neuroscience, 187, 24-35 (2011-04-19)
Psychiatric illness and anxiety disorders have strong neurodevelopmental components. Environmental insults such as prenatal exposure to stress and genetic differences in stress responses may affect brain development. A rat model of random variable prenatal stress was used to study the
P P Roux et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 6887-6896 (1999-08-06)
Seizure causes neuronal cell loss in both animal models and human epilepsy. To determine the contribution of apoptotic mechanisms to seizure-induced neuronal cell death, rat brains were examined for the occurrence of terminal deoxynucleotidyl transferase-mediated UTP nick end labeling (TUNEL)-positive
Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.
Mysona, BA; Al-Gayyar, MM; Matragoon, S; Abdelsaid, MA; El-Azab, MF; Saragovi, HU; El-Remessy, AB
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