V-042

Vitamin K2 (MK-4)-¹³C₆ solution

10 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant^®

• Synonym(s): 13C6-Labeled Vitamin K2 (MK-4)
• Empirical Formula (Hill Notation): C₂₅₁₃C₆H₄₀O₂
• Molecular Weight: 30327.27
• MDL number: MFCD00079646
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 10 μg/mL in acetonitrile
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −70°C

Description

General description

This stable-labeled internal standard is suitable for quantification of vitamin K2 (MK-4) in LC-MS/MS clinical testing applications such as assessment of vitamin K2 deficiency and research of VKD proteins. Vitamin K2 (MK-4) or menaquinone-4 is an essential cofactor for enzymes that activate blood-clotting factors as well as vitamin K-dependent (VKD) proteins involved in bone metabolism, arterial calcification, growth control, and signal transduction.

Application

• Menaquinone-4 prevents medication-related osteonecrosis of the jaw: Utilizing Vitamin K2 (MK-4)-¹³C₆, this research highlights its potential in preventing osteonecrosis via SIRT1 signaling, crucial for reducing osteoblast apoptosis under metabolic stresses, beneficial for pharmaceutical studies related to bone health and safety (Cui et al., 2023).


• Reference Range of Vitamin K Evaluating Indicators in Chinese Childbearing Women: This study uses ¹³C₆-labeled Vitamin K2 (MK-4) to establish reference ranges for vitamin K, critical for understanding its bioavailability in populations at risk of deficiency, aiding in nutritional assessments and supplement development (Nie et al., 2023).


• Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4: The application of Vitamin K2 (MK-4)-¹³C₆ in LC-MS methods enhances the accuracy of measuring vitamin K levels in serum without supplementation, providing vital data for clinical diagnostics and nutritional research (Meinitzer et al., 2022).


• Vitamin K (phylloquinone and menaquinones) in foods: Research uses Vitamin K2 MK-4-¹³C₆ for cost-effective quantification in foods via LC-ESI-MS/MS, supporting efforts in food science to accurately report vitamin K content, which is essential for consumer health and regulatory compliance (Jensen et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2.0 °C - closed cup