700044P
Avanti
7β-hydroxycholesterol-d7
Avanti Research™ - A Croda Brand
Synonym(s):
cholest-5-ene-3b,7b-diol(d7)
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1 MG
$599.46
About This Item
Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
Molecular Weight:
409.70
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.25
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description
cholest-5-en-3β,7β-diol-d7
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700044P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol.[1] 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
Application
7β-hydroxycholesterol-d7 has been used:
- as cholesterol oxidation product for mass spectroscopy analysis[2]
- as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis[3]
- as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry[4]
- as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification[5]
Biochem/physiol Actions
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice.[6] 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.[1]
Packaging
5 mL Amber Glass Screw Cap Vial (700044P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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Virginie Aires et al.
Scientific reports, 9(1), 9134-9134 (2019-06-27)
Obesity may not be consistently associated with metabolic disorders and mortality later in life, prompting exploration of the challenging concept of healthy obesity. Here, the consumption of a high-fat/high-sucrose (HF/HS) diet produces hyperglycaemia and hypercholesterolaemia, increases oxidative stress, increases endotoxaemia
Changguang Wang et al.
International journal of pharmaceutics, 569, 118576-118576 (2019-07-31)
Cholesterol is one of the major structural constituents in a liposomal bilayer. Cholesterol is susceptible to various reactions in the presence of oxygen, heat, light, certain metals, and radicals during manufacturing or storage, which may cause to generate cholesterol oxidation
Zoltán Pataj et al.
Journal of chromatography. A, 1439, 82-88 (2015-11-27)
Oxysterols are important intermediates in numerous metabolic and catabolic pathways and their biological significance is also proven. The present paper describes a reliable and short liquid chromatography-high-resolution mass spectrometry method (LC-MS/HR-MS) for the quantification of 8 different oxysterols (24(S)-hydroxycholesterol, 25-hydroxycholesterol
Guilherme Silva Ferreira et al.
Frontiers in physiology, 8, 644-644 (2017-09-21)
Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis, uptake, and exportation besides mediating inflammation and cytotoxicity that modulate the development of atherosclerosis. Aerobic exercise training (AET) prevents and regresses atherosclerosis by the improvement of lipid metabolism, reverse cholesterol
Sonja Kunz et al.
The Journal of steroid biochemistry and molecular biology, 190, 99-103 (2019-03-30)
The human gut microbiome plays a crucial role in both health and disease. Metabolites in human faeces related to microbial activity might therefore be attractive surrogate markers to track changes of microbiota induced by diet or disease. The hyphenation of
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