Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

933562

Sigma-Aldrich

NanoFabTx™ - Synthetic Folate Lipid Mix

for synthesis of folate functionalized liposomes for targeted delivery

Synonym(s):

Cholesterol, Drug delivery, Folate-PEG-DSPE, Hydro Soy PC, LNP, Microfluidics, NanoFab reagent kit, Nanoformulation, Nanoparticle, PE-PEG

Sign Into View Organizational & Contract Pricing

Select a Size

933562-25MG
$565.00
933562-100MG
$1,990.00

$565.00

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
933562-25MG
$565.00
933562-100MG
$1,990.00

About This Item

UNSPSC Code:
12352211
NACRES:
NA.21

$565.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

storage temp.

−20°C

Application

NanoFabTx™ Synthetic Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to synthesize liposomes around 100 nm with low polydispersity
  • Lipid mix optimized for folate-functionalized liposomes for small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:

  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCT6970
MKCT6969

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mahmoud M Omar et al.
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Yan Tie et al.
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study
Amit Verma et al.
Pharmaceutical research, 36(8), 123-123 (2019-06-21)
This investigation was aimed to explore the targeting potential of folate conjugated double liposomes (fDLs) bearing combination of synergistic drugs (Prednisolone and Methotrexate) for effective management of the rheumatoid arthritis (RA). To overcome the drawbacks of monotherapy, a combination of
Ho Yub Yoon et al.
International journal of nanomedicine, 14, 6249-6268 (2019-09-10)
To develop an intravesical instillation system for the treatment of bladder cancer, rapamycin (Rap) was encapsulated into liposomes and then homogeneously dispersed throughout a poloxamer 407 (P407)-based hydrogel. Rap-loaded conventional liposomes (R-CL) and folate-modified liposomes (R-FL) were prepared using a

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service