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327115

Sigma-Aldrich

o-Toluidine hydrochloride

98%

Synonym(s):

2-Methylaniline hydrochloride

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About This Item

Linear Formula:
CH3C6H4NH2 · HCl
CAS Number:
Molecular Weight:
143.61
Beilstein:
3558629
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

Assay

98%

mp

215-217 °C (lit.)

SMILES string

Cl.Cc1ccccc1N

InChI

1S/C7H9N.ClH/c1-6-4-2-3-5-7(6)8;/h2-5H,8H2,1H3;1H

InChI key

OGVXWEOZQMAAIM-UHFFFAOYSA-N

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General description

o-Toluidine hydrochloride is a demonstrated animal carcinogen.[1]

Application

o-Toluidine hydrochloride was used in preparation of 9,9-bis(3-methyl-4-aminophenyl)fluorine.[2]

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M Elwell
Toxicity report series, 44, 1-C8-1-C8 (2002-07-16)
o-Nitrotoluene and o-toluidine hydrochloride are structurally related chemicals that are suspected and demonstrated animal carcinogens, respectively. The metabolic potential of the gastrointestinal flora is considered an important factor in o-nitrotoluene-induced toxicity and involves the reduction of the nitro group to
Ortho alkyl substituents effect on solubility and thermal properties of fluorenyl cardo polyimides.
Hu Z, et al.
Polymer, 46(14), 5278-5283 (2005)
Tania Carreón et al.
Occupational and environmental medicine, 67(5), 348-350 (2009-11-04)
In 1991, the US National Institute for Occupational Safety and Health (NIOSH) reported an increased bladder cancer risk in a cohort of 1749 workers potentially exposed to o-toluidine and aniline at a chemical manufacturing plant. As additional information showed that
Arnaldo D'Amico et al.
Lung cancer (Amsterdam, Netherlands), 68(2), 170-176 (2009-12-05)
The use of gas sensor arrays as medical diagnosis instruments has been proposed several years ago. Since then, the idea has been proven for a limited number of diseases. The case of lung cancer is particularly interesting because it is
Jin Anotai et al.
Environmental science and pollution research international, 19(1), 169-176 (2011-06-28)
The optimal conditions of o-toluidine degradation by fluidized-bed Fenton process were determined using Box-Behnken designs (BBD). The BBD can be used to find the optimal conditions in multivariable systems. The optimal conditions obtained by the design were further applied in

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