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291196

Sigma-Aldrich

Creatine

98%

Synonym(s):

(α-Methylguanido)acetic acid, N-Amidinosarcosine

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About This Item

Linear Formula:
H2NC(=NH)N(CH3)CH2CO2H
CAS Number:
Molecular Weight:
131.13
Beilstein:
907175
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

98%

SMILES string

CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

InChI key

CVSVTCORWBXHQV-UHFFFAOYSA-N

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Biochem/physiol Actions

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP.
Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

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Samit Malhotra et al.
Continuum (Minneapolis, Minn.), 19(1 Sleep Disorders), 67-85 (2013-02-13)
This review discusses the various causes of primary hypersomnias with emphasis on clinical recognition, diagnosis, and treatment options. Narcolepsy is probably the most fascinating syndrome causing excessive daytime sleepiness. With increasing understanding of the hypocretin/orexin pathways and the neurotransmitters that
Creatine--a dispensable metabolite?
Heinrich Taegtmeyer et al.
Circulation research, 112(6), 878-880 (2013-03-16)
You're the flight surgeon. Nutritional supplements.
John Reaume
Aviation, space, and environmental medicine, 84(1), 81-83 (2013-01-12)
An-Chih Chen et al.
Acta neurologica Taiwanica, 22(1), 26-31 (2013-03-13)
Acute motor axonal neuropathy (AMAN), a variant of Guillain Barre syndrome (GBS), is frequently induced by the antecedent infection of some atypical pathogen, such as Campylobacter jejuni, Mycoplasma pneumonia and some virus. It is generally accepted that corticosteroids and immunosuppressants
Alexandra Trotier-Faurion et al.
Journal of medicinal chemistry, 56(12), 5173-5181 (2013-05-24)
The creatine transporter deficiency is a neurological disease caused by impairment of the creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of creatine within the brain and cellular energy perturbation of neuronal cells. One of the

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