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Key Documents

195413

Sigma-Aldrich

Methacrylonitrile

99%

Synonym(s):

1-Methylethenyl cyanide, 2-Cyano-1-propene, 2-Methyl-2-propenenitrile, 2-Methylpropenenitrile, Isobutenenitrile, Isopropene cyanide, Methacrylnitrile

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About This Item

Linear Formula:
CH2=C(CH3)CN
CAS Number:
Molecular Weight:
67.09
Beilstein:
773708
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:

vapor pressure

64 mmHg ( 20 °C)

Assay

99%

contains

50 ppm monomethyl ether hydroquinone as inhibitor

refractive index

n20/D 1.400 (lit.)

bp

90-92 °C (lit.)

mp

−35.8 °C (lit.)

density

0.8 g/mL at 25 °C (lit.)

SMILES string

CC(=C)C#N

InChI

1S/C4H5N/c1-4(2)3-5/h1H2,2H3

InChI key

GYCMBHHDWRMZGG-UHFFFAOYSA-N

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Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Flam. Liq. 2 - Skin Sens. 1 - STOT SE 1

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

53.6 °F - closed cup

Flash Point(C)

12 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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B I Ghanayem et al.
Carcinogenesis, 18(4), 675-680 (1997-04-01)
Acrylonitrile (AN) and methacrylonitrile (MAN) are two major industrial nitriles used in the production of plastics and acrylic fibers. Whereas AN is a potent acute toxin and carcinogenic in rats, little is known regarding MAN. Current work is part of
Mohammed Y H Farooqui et al.
Research communications in molecular pathology and pharmacology, 120-121(1-6), 79-92 (2007-01-01)
This study reports the toxicity and metabolism of methacrylonitrile (MeAN) in normal male Sprague-Dawley rats and those pre-treated with caffeine, alcohol or both. Rats were divided into groups often. One group received an oral dose by gavage of 6 %
Cytotoxicity of methacrylonitrile.
V Vasanthakumari et al.
Bulletin of environmental contamination and toxicology, 59(2), 274-278 (1997-08-01)
J D George et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 34(2), 249-259 (1996-12-01)
Timed-pregnant Sprague-Dawley (CD) outbred rats and New Zealand White rabbits were dosed by gavage with methacrylonitrile (MACR) in distilled water during major organogenesis. Rats were dosed on Gestational Days (GD) 6 through 15 (0, 5, 25, or 50 mg MACR/kg/day)
Birgit Grill et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-03)
Nitrile hydratases (NHase) catalyze the hydration of nitriles to the corresponding amides. We report on the heterologous expression of various nitrile hydratases. Some of these enzymes have been investigated by others and us before, but sixteen target proteins represent novel

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