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Sigma-Aldrich

2-Adamantylamine hydrochloride

99%

Synonym(s):

2-Adamantanamine hydrochloride, 2-Aminoadamantane hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H17N · HCl
CAS Number:
10523-68-9
Molecular Weight:
187.71
Beilstein:
4297901
EC Number:
234-074-2
MDL number:
MFCD00074743
UNSPSC Code:
12352100
PubChem Substance ID:
24849376
NACRES:
NA.22

Assay

99%

form

solid

mp

>300 °C (lit.)

SMILES string

Cl.NC1[C@@H]2C[C@H]3C[C@@H](C2)C[C@@H]1C3

InChI

1S/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?;

InChI key

WLDWDRZITJEWRJ-ZDAMNCSYSA-N

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General description

The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.

Application

2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2′-(carboxymethoxime)-olivomycin I.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yasuhiko Higashi et al.
Biomedical chromatography : BMC, 20(5), 423-428 (2005-09-15)
Simultaneous HPLC assay of 1-adamantanamine hydrochloride (amantadine) and its four related compounds [2-adamantanamine hydrochloride (2-ADA), 1-adamantanmethylamine (ADAMA), 1-(1-adamantyl)ethylamine hydrochloride (rimantadine) and 3,5-dimethyl-1-adamantanamine hydrochloride (memantine)] in phosphate-buffered saline (pH 7.4) after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) was developed. Phosphate-buffered saline samples
S V Krapivin et al.
Biulleten' eksperimental'noi biologii i meditsiny, 116(11), 515-518 (1993-11-01)
The action of the new stimulant bromantane on spectra power EEG on Fourier of sensorimotor cortex, dorsal hippocamp and lateral hypothalamus of left and right hemispheres of brain of rat in free behavior was investigated. Bromantane leads to decreases in
Alina A Okhina et al.
Journal of pharmaceutical and biomedical analysis, 180, 113039-113039 (2019-12-23)
A method of quantitative determination of camphecene, a new anti-influenza agent, in rat blood plasma based on LC-MS/MS was developed, validated and used to study the distribution of the agent between blood cells and blood plasma. The method was validated
C Clark et al.
Immunopharmacology, 21(1), 41-50 (1991-01-01)
The present in vitro investigations on amantadine (AmTd) and its isomer 2-aminoadamantane (2-NH2-Adam), and the corresponding analogs, 1-nitroadamantane (1-NO2-Adam) and 2-nitroadamantane (2-NO2-Adam), were undertaken to gain information about molecular features that might have a dominant role in inhibiting T lymphocyte
Anna N Tevyashova et al.
The Journal of antibiotics, 62(1), 37-41 (2009-01-10)
A novel way of chemical modification of the antibiotic olivomycin I at the 2'-keto group of the side chain of the aglycone moiety was developed. Reaction of olivomycin I with the carboxymethoxylamine hemihydrochloride gave the key intermediate, 2'-carboxymethoxime-olivomycin I, which
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