U3385

UA62784

≥98% (HPLC)

• Synonym(s): 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
• Empirical Formula (Hill Notation): C₂₃H₁₅NO₃
• CAS Number: 313367-92-9
• Molecular Weight: 353.37
• NACRES: NA.77
• PubChem Substance ID: 329827627
• UNSPSC Code: 12352202
• MDL number: MFCD00489199
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: >2 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
• InChI: 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
• InChI key: SVICLWPFAQYZLX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.

Preparation Note

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable