Skip to Content
Merck
All Photos(1)

Documents

SRP4011

Sigma-Aldrich

Cardiotrophin-1 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

CT1, CTF1, Cardiophin 1

Sign Into View Organizational & Contract Pricing


About This Item

MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

~22.5 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CTF1(1489)

General description

Cardiotrophin-1 belongs to the interleukin-6 (IL-6) family of cytokines. It is a cytoprotective protein. The gene is mapped to human chromosome 16p11.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.

Biochem/physiol Actions

Cardiotrophin-1 signals via β receptor glycoprotein 130 (gp130) and β receptor leukemia inhibitory factor receptor (LIFR). It confers protective role on cardiac myocytes. Cardiotrophin-1 protects cardiomyocytes from cell death, however, it can also induce cardiac hypertrophy. It is also involved in neural tissue development and helps in protection of the mature nervous system from injuries and dysfunction. Cardiotrophin-1 also protects liver against injury. It is also involved in the control of body weight and intermediate metabolism. In mouse model, it protects β cells from apoptosis. It also promotes glucose-mediated insulin secretion. Absence of the cardiotrophin-1 gene in mice is associated with obesity, hyperglycemia, hyperinsulinemia and hypercholesterolemia.

Physical form

Sterile filtered and then lyophilized in 1 x PBS.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 20 mM Tris, pH 8.0 to a concentration of <1.0 mg/mL. The solution can be diluted into other aqueous buffers.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cardiotrophin-1: A multifaceted cytokine.
Lopez-Yoldi M, et al.
Cytokine & Growth Factor Reviews, 26, 523-523 (2015)
Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.
Hung HC, et al.
Scientific Reports, 5, 17438-17438 (2015)
Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.
Lutz SZ, et al.
PLoS ONE, 9, e100391-e100391 (2014)
Alejandro Aranda et al.
Cellular and molecular life sciences : CMLS, 71(23), 4637-4651 (2014-05-06)
We report a new method to generate high-expressing mammalian cell lines in a quick and efficient way. For that purpose, we developed a master cell line (MCL) containing an inducible alphavirus vector expressing GFP integrated into the genome. In the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service