SML3485

PFI-7 hydrochloride

≥98% (HPLC)

• Synonym(s): N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-((1H-indol-2-yl)methylamino)acetamide hydrochloride
• Empirical Formula (Hill Notation): C₂₄H₂₇N₅O _{· xHCl}
• Molecular Weight: 401.50 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.28
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(CNCC1=CC2=C(N1)C=CC=C2)N[C@@H]3CC[C@@H](CC3)C4=NC5=C(N4)C=CC=C5
• InChI key: HLHNFJNSQZZUNW-MAEOIBBWSA-N

Description

Biochem/physiol Actions

PFI-7 is a high affinity E3 ligase GID4 probe (KD = 0.08 μM by SPR) that competes against cellular degrons for full-length GID4 binding with high potency (EC50 = 0.6 μM by cell-based NanoBRET).

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable