SML2833

JTE-607

≥98% (HPLC), cytokine release inhibitor, powder

• Synonym(s): (-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate dihydrochloride, JTE 607, N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
• Empirical Formula (Hill Notation): C₂₅H₃₁Cl₂N₃O₅·2HCl
• CAS Number: 188791-09-5
• Molecular Weight: 597.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD07363998
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: JTE-607, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Clc1c(c(cc(c1O)C(=O)N[C@@H](Cc3ccccc3)C(=O)OCC)Cl)OCCN2CCN(CC2)C.Cl.Cl
• InChI: 1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1
• InChI key: JUJAUEQJEWIWCQ-FJSYBICCSA-N

Description

Biochem/physiol Actions

JTE-607 is a pro-drug, which carboxylic form (JTE-607-COOH) is a potent cytokine release inhibitor. JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia. It also inhibits proliferation of AML cell in vitro and in xenograft model. JTE-607 is an inhibitor of CPSF3 (pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3) that directly binds to CPSF3 and blocks the release of newly synthesized pre-mRNAs.

pro-drug of cytokine release inhibitor JTE-607-COOH; inhibitor of CPSF3

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable