SML2533

Jedi1

≥98% (HPLC), Piezo1 channel activator, powder

• Synonym(s): 2-Methyl-5-phenyl-3-furancarboxylic acid, 2-Methyl-5-phenyl-3-furoic acid, 2-Methyl-5-phenylfuran-3-carboxylic acid, 5-Phenyl-2-methyl-3-furancarboxylic acid
• Empirical Formula (Hill Notation): C₁₂H₁₀O₃
• CAS Number: 108124-17-0
• Molecular Weight: 202.21
• UNSPSC Code: 12352302
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Jedi1, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [O-]C(=O)c1c([o]c(c1)c2ccccc2)C
• InChI: 1S/C12H10O3/c1-8-10(12(13)14)7-11(15-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,13,14)/p-1
• InChI key: VLMNACSEESRUAK-UHFFFAOYSA-M

Description

Biochem/physiol Actions

Jedi1 is an activator of the mechanosensitive Piezo1 channel that binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.

Piezo1 channel activator

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable