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Key Documents

SML2470

Sigma-Aldrich

GYY4137 sodium, dichloromethane-free

≥98% (HPLC)

Synonym(s):

(4-Methoxyphenyl)-4-morpholinyl-phosphinodithioic acid, sodium salt, GYY4137 Na salt, GYY4137 sodium salt, Na-GYY4137, Sodium 4-methoxyphenyl(morpholino)phosphinodithioate, Sodium GYY4137

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About This Item

Empirical Formula (Hill Notation):
C11H15NNaO2PS2
CAS Number:
Molecular Weight:
311.34
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

[S-]P(C1=CC=C(C=C1)OC)(N2CCOCC2)=S.[Na+]

Biochem/physiol Actions

GYY4137 sodium (Na-GYY4137) is a dichloromethane-free, water-soluble sodium salt form of the slow-releasing hydrogen sulfide (H2S) donor GYY4137. Na-GYY4137 is devoid of potential off-target effects associated with the use of dichloromethane-complexed GYY4137 morpholine salt form. Morpholine is biologically active and toxic (LD50 range of 300-500 mg/kg in rodents), while dichloromethane is carcinogenic and can metabolize in vivo to carbon monoxide, causing unintended CO-dependent effects.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137
Lehto SG, Weyer AD, Youngblood BD, Zhang M, Yin R, Wang W, Teffera Y, Cooke M, Stucky CL, et al
MedChemComm, 6, 1649-1655 (2015)
Eva Latorre et al.
Aging, 10(7), 1666-1681 (2018-07-22)
Cellular senescence is a key driver of ageing, influenced by age-related changes to the regulation of alternative splicing. Hydrogen sulfide (H2S) has similarly been described to influence senescence, but the pathways by which it accomplishes this are unclear.We assessed the

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