SML2348

BAY-707

≥98% (HPLC)

• Synonym(s): (S)-N-Ethyl-4-(3-methylmorpholino)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
• Empirical Formula (Hill Notation): C₁₅H₂₀N₄O₂
• CAS Number: 2109805-96-9
• Molecular Weight: 288.34
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(NCC)C1=CC2=C(N1)N=CC=C2N3CCOC[C@@H]3C
• InChI: 1S/C15H20N4O2/c1-3-16-15(20)12-8-11-13(4-5-17-14(11)18-12)19-6-7-21-9-10(19)2/h4-5,8,10H,3,6-7,9H2,1-2H3,(H,16,20)(H,17,18)/t10-/m0/s1
• InChI key: RPMGXDCRCWWCRY-JTQLQIEISA-N

Description

Biochem/physiol Actions

BAY-707 is an inhibitor of the human 7,8-dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1), which hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage. BAY-707 was shown to be a substrate-competitive, selective MTH1 inhibitor with an IC50 value of 2.3 nM.

Inhibitor of the human 7,8-dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable