SML1848

PCS1055 dihydrochloride

≥98% (HPLC)

• Synonym(s): 6,7-Dihydro-N-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-amine dihydrochloride
• Empirical Formula (Hill Notation): C₂₇H₃₂N₄ · 2HCl
• CAS Number: 361979-40-0
• Molecular Weight: 485.49
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [H]Cl.[H]Cl.C12=C(N=NC(NCCC3CCN(CC4=CC=CC=C4)CC3)=C2)C5=C(C=CC=C5)CCC1
• InChI: 1S/C27H32N4.2ClH/c1-2-7-22(8-3-1)20-31-17-14-21(15-18-31)13-16-28-26-19-24-11-6-10-23-9-4-5-12-25(23)27(24)30-29-26;;/h1-5,7-9,12,19,21H,6,10-11,13-18,20H2,(H,28,29);2*1H
• InChI key: VSCSFYDNGYAWKG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PCS1055 is a potent and selective muscarinic M4 acetylcholine receptor competitive antagonist that exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 was originally described as a potent electric eel AChE inhibitor (IC50 = 22 nM) and less potent at human AChE (IC50 = 120 nM).

Potent and selective muscarinic M4 receptor antagonist

Safety Information

• hcodes: H413
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3