SML1685

Ribocil-C

≥98% (HPLC), Riboflavin riboswitch inhibitor, powder

• Synonym(s): 2-[(3S)-1-[[1-(2-Pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-4(3H)-pyrimidinone
• Empirical Formula (Hill Notation): C₂₁H₂₁N₇OS
• CAS Number: 1825355-56-3
• Molecular Weight: 419.50
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD29472282
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Ribocil-C, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1NC([C@@]2([H])CCCN(CC3=CN(C4=NC=CC=N4)C=N3)C2)=NC(C5=CC=CS5)=C1

Description

Biochem/physiol Actions

Ribocil-C is a potent inhibitor of bacterial riboflavin riboswitches.

Ribocil-C is a potent inhibitor of bacterial riboflavin riboswitches. Riboswitches are cis regulatory elements present in non-coding RNA that specifically bind to natural ligands to regulate gene expression. Ribocil-C blocks the flavin mononucleotide riboswitch-mediated expression of the ribB gene, which is required for riboflavin biosynthesis, with an IC₅₀ value of 23 nM. Ribocil-C inhibited bacterial cell growth of E. coli MB5746 and bacterial burden in a mouse E. coli septicaemia model of infection.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable