SML0786

Decursin

From Radix peucedani, ≥97% (HPLC), anticancer agent, powder

• Synonym(s): (+)-Decursin, (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate, 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester
• Empirical Formula (Hill Notation): C₁₉H₂₀O₅
• CAS Number: 5928-25-6
• Molecular Weight: 328.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00272154
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• Product Name: Decursin, ≥97% (HPLC)
• biological source: Radix peucedani
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D +120 to +160°, c = 0.5 in chloroform-d
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [o]1c2c(cc3c(c2)OC([C@H](C3)OC(=O)C=C(C)C)(C)C)cc[c]1=O
• InChI: 1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
• InChI key: CUKSFECWKQBVED-INIZCTEOSA-N

Description

Biochem/physiol Actions

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant.

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable