SML0296

Pyroxamide

≥97% (HPLC)

• Synonym(s): N1-Hydroxy-N8-3-pyridinyl-octanediamide
• Empirical Formula (Hill Notation): C₁₃H₁₉N₃O₃
• CAS Number: 382180-17-8
• Molecular Weight: 265.31
• NACRES: NA.77
• PubChem Substance ID: 329825303
• UNSPSC Code: 12352200
• MDL number: MFCD13194970
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• storage temp.: −20°C
• SMILES string: ONC(=O)CCCCCCC(=O)Nc1cccnc1
• InChI: 1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
• InChI key: PTJGLFIIZFVFJV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Pyroxamide is an inhibitor of HDAC1 (IC₅₀ = 100 nM). Pyroxamide induces apoptosis and cell cycle arrest in leukemia, bladder and prostate cancer cell lines.

Pyroxamide is an inhibitor of HDAC1.

Safety Information

• Hazard Classifications: Acute Tox. 4 Oral
• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable