SML0176

Z36

≥98% (HPLC)

• Synonym(s): (Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one, 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
• Empirical Formula (Hill Notation): C₂₃H₂₄FN₃O₂
• CAS Number: 1243148-19-7
• Molecular Weight: 393.45
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825205
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to dark yellow
• solubility: DMSO: ≥15 mg/mL
• storage temp.: −20°C
• SMILES string: COc1ccc2[nH]cc(\C=C3/C(=O)N(CCCN(C)C)c4ccc(F)cc34)c2c1
• InChI: 1S/C23H24FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h5-8,11-14,25H,4,9-10H2,1-3H3/b20-11-
• InChI key: CQNOITUXWKRVMB-JAIQZWGSSA-N

Description

Application

Z36 may be used to study cell signaling that results in autophagy.

Biochem/physiol Actions

Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis

Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.

Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable