SAB4500249
Anti-PARK7 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Oncogene DJ1, Parkinson disease protein 7, Protein DJ-1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 19 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PARK7(11315)
General description
Anti-PARK7 Antibody detects endogenous levels of total PARK7 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human PARK7.
Immunogen Range: 61-110
Immunogen Range: 61-110
Application
Anti-PARK7 antibody produced in rabbit is suitable for indirect ELISA and western blot applications.
Biochem/physiol Actions
PARK7 is a member of novel glyoxalase family. It exerts mitochondrial activity. It has been suggested that PARK7 may act as an antioxidant and/or a molecular chaperone. It may also detoxify aggressive metabolic aldehyde by-products. It helps in stabilizing mitochondria during cellular stress. Alteration in gene function affects neurodegeneration, which leads to the autosomal recessive early-onset parkinsonism.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Jacek R Wiśniewski et al.
Journal of proteome research, 15(7), 2321-2326 (2016-06-15)
Proteomics and other protein-based analysis methods such as Western blotting all face the challenge of discriminating changes in the levels of proteins of interest from inadvertent changes in the amount loaded for analysis. Mass-spectrometry-based proteomics can now estimate the relative
Yusuke Toyoda et al.
Biology open, 3(8), 777-784 (2014-07-27)
Parkinson's disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra. One of the genes linked with the onset of Parkinson's disease, DJ-1/PARK7, belongs to a novel glyoxalase family and influences mitochondrial activity. It has been assumed
V Bonifati et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 24(3), 159-160 (2003-11-05)
Four chromosomal loci ( PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. We mapped the PARK7 locus to chromosome 1p36 in a large family from a genetically isolated population in the Netherlands, and confirmed
Vincenzo Bonifati et al.
Science (New York, N.Y.), 299(5604), 256-259 (2002-11-26)
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the
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