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S7942

Sirtinol

≥95% (HPLC)

Synonym(s):

2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C26H22N2O2
CAS Number:
410536-97-9
Molecular Weight:
394.47
NACRES:
NA.77
PubChem Substance ID:
24899771
UNSPSC Code:
12352203
MDL number:
MFCD00810186
Assay:
≥95% (HPLC)
Form:
solid
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Quality Segment

200

assay

≥95% (HPLC)

form

solid

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4

InChI

1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+

InChI key

UXJFDYIHRJGPFS-WPWMEQJKSA-N

Gene Information

human ... SIRT1(23411), SIRT2(22933)

Application

HUVEC were treated with sirtinol to study the effect on induction of transcription factor Krüppel-like factor 2.4 Sirtinol was used to treat human embryonic kidney cells to study the effect on the expression on Werner syndrome protein.5

Biochem/physiol Actions

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p and human SIRT2 deacetylase activity in vitro. It inhibits the physiological regulators of platelet aggregation such as thrombin and collagen, attenuates intracellular Ca2+ release and formation thromboxane B2. It may increase levels of cAMP by inhibition of cAMP phosphodiesterase and inhibit the aggregation of platelets.2 Sirtinol reduces inflammatory responses of human dermal microvascular endothelial cells to TNF-α and IL-1β.3
Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p, and human SIRT2 deacetylase activity in vitro.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
566320566321SML1620
Sirtinol ≥95% (HPLC)

Sigma-Aldrich

S7942

Sirtinol

Sirtinol A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1.

Sigma-Aldrich

566320

Sirtinol

Sirtinol InSolution, ≥97%, inhibitor of sirtuin class of histone deacetylase (HDAC) activity

Sigma-Aldrich

566321

Sirtinol

NGI-1 ≥95% (HPLC)

Sigma-Aldrich

SML1620

NGI-1

form

solid

form

solid

form

liquid

form

powder

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble

solubility

DMSO: 1 mg/mL

solubility

-

solubility

DMSO: 5 mg/mL, clear (warmed)

Gene Information

human ... SIRT1(23411), SIRT2(22933)

Gene Information

-

Gene Information

-

Gene Information

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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