S5013

Salbutamol hemisulfate salt

≥98%

• Synonym(s): α-([t-Butylamino]methyl)-4-hydroxy-m-xylene-α,α′-diol, Albuterol
• Linear Formula: C₁₃H₂₁NO₃ · 1/2H₂SO₄
• CAS Number: 51022-70-9
• Molecular Weight: 288.35
• EC Number: 256-916-8
• MDL number: MFCD00055200
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277746
• NACRES: NA.77

Properties

• Assay: ≥98%
• solubility: 1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green
• originator: GlaxoSmithKline
• SMILES string: OS(O)(=O)=O.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c2ccc(O)c(CO)c2
• InChI: 1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
• InChI key: BNPSSFBOAGDEEL-UHFFFAOYSA-N
• Gene Information: human ... ADRB2(154)

Description

Application

Salbutamol hemisulfate salt has been used as reference standards of drugs for the validation of β-agonist residue.

Salbutamol hemisulfate salt was used as standard in analysis of fortified meat for LABA content using ELISA kits.³ It was used to study the response of prostaglandin 2α to various β-adrenergic agonists in cultured bovine endometrial cells.⁴

Biochem/physiol Actions

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP). Salbutamol is particularly effective in treatment of asthma as it provides immediate relief. Salbutamol is one of the most popular short-acting BA (SABA). It is useful in treating the symptoms of EIB (exercise induced bronchospasm).

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).¹ Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.²

β2-Adrenergic receptor agonist.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H317,H351,H361fd
• Precautionary Statements: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Carc. 2 - Repr. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves